M. leprae components induce nerve damage by complement activation: identification of lipoarabinomannan as the dominant complement activator
نویسندگان
چکیده
منابع مشابه
Immunologic identification of M. leprae. Immunofluorescence and complement fixation.
A markedly improved immunofluorescent technic employing FITC conjugated IgG antibody prepared from lepromatous serum is described as a means of specific identification of M. leprae. An additional immunologic identification method for M. leprae is presented as a micro-complement fixation technic employing antigen rather than antibody dilution. Studies with these technics suggest that M. leprae s...
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متن کاملActivation of complement by Mycobacterium leprae requires disruption of the bacilli.
OBJECTIVE The immune-mediated events that precipitate erythema nodosum leprosum (ENL) are not well understood. One component may be the complexing of antibody with antigens released from infected macrophages, the activation of complement and the subsequent local inflammation. We assess here the ability of highly-purified, disrupted M. leprae, to activate complement. RESULTS Intact and sonical...
متن کاملIn vitro thalidomide does not interfere with the activation of complement by Mycobacterium leprae
One inflammatory event that may be involved in erythema nodosum leprosum (ENL) is the activation of complement, and thalidomide could suppress ENL by inhibiting its activation. To determine if thalidomide inhibits the activation of complement, we first incubated normal serum with Mycobacterium leprae or with zymosan in the presence of thalidomide. Residual functional complement was then determi...
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ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2015
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-015-1404-5